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Document type:
journal article 
Author(s):
Rebholz, B; Haase, I; Eckelt, B; Paxian, S; Flaig, MJ; Ghoreschi, K; Nedospasov, SA; Mailhammer, R; Debey-Pascher, S; Schultze, JL; Weindl, G; Förster, I; Huss, R; Stratis, A; Ruzicka, T; Röcken, M; Pfeffer, K; Schmid, RM; Rupec, RA 
Title:
Crosstalk between keratinocytes and adaptive immune cells in an IkappaBalpha protein-mediated inflammatory disease of the skin. 
Abstract:
Inflammatory diseases at epithelial borders develop from aberrant interactions between resident cells of the tissue and invading immunocytes. Here, we unraveled basic functions of epithelial cells and immune cells and the sequence of their interactions in an inflammatory skin disease. Ubiquitous deficiency of the IkappaBalpha protein (Ikba(Delta)(/Delta)) as well as concomitant deletion of Ikba specifically in keratinocytes and T cells (Ikba(K5Delta/K5Delta lckDelta/lckDelta)) resulted in an inf...    »
 
Journal title abbreviation:
Immunity 
Year:
2007 
Journal volume:
27 
Journal issue:
Pages contribution:
296-307 
Language:
eng 
Print-ISSN:
1074-7613 
TUM Institution:
II. Medizinische Klinik und Poliklinik