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Dokumenttyp:
journal article 
Autor(en):
Algül, H; Wagner, M; Lesina, M; Schmid, RM 
Titel:
Overexpression of ErbB2 in the exocrine pancreas induces an inflammatory response but not increased proliferation. 
Abstract:
Tyrosine kinase receptors such as members of the epidermal growth factor receptor family and their respective ligands are frequently overexpressed in pancreatic cancer as well as in chronic pancreatitis. In this study, the role of ErbB2 in the exocrine pancreas was examined by ectopic overexpression under the control of the proximal rat elastase promoter. Three independent transgenic mouse lines overexpressing ErbB2 were established by pronuclear injection. Pancreatic mRNA and protein levels wer...    »
 
Zeitschriftentitel:
Int J Cancer 
Jahr:
2007 
Band / Volume:
121 
Heft / Issue:
Seitenangaben Beitrag:
1410-6 
Sprache:
eng 
Print-ISSN:
0020-7136 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik