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Document type:
journal article 
Author(s):
Algül, H; Wagner, M; Lesina, M; Schmid, RM 
Title:
Overexpression of ErbB2 in the exocrine pancreas induces an inflammatory response but not increased proliferation. 
Abstract:
Tyrosine kinase receptors such as members of the epidermal growth factor receptor family and their respective ligands are frequently overexpressed in pancreatic cancer as well as in chronic pancreatitis. In this study, the role of ErbB2 in the exocrine pancreas was examined by ectopic overexpression under the control of the proximal rat elastase promoter. Three independent transgenic mouse lines overexpressing ErbB2 were established by pronuclear injection. Pancreatic mRNA and protein levels wer...    »
 
Journal title abbreviation:
Int J Cancer 
Year:
2007 
Journal volume:
121 
Journal issue:
Pages contribution:
1410-6 
Language:
eng 
Print-ISSN:
0020-7136 
TUM Institution:
II. Medizinische Klinik und Poliklinik