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Document type:
journal article 
Author(s):
Bourteele, S; Oesterle, K; Weinzierl, AO; Paxian, S; Riemann, M; Schmid, RM; Planz, O 
Title:
Alteration of NF-kappaB activity leads to mitochondrial apoptosis after infection with pathological prion protein. 
Abstract:
Nuclear factor kappa B (NF-kappaB) is a key regulator of the immune response, but in almost the same manner it is involved in induction of inflammation, proliferation and regulation of apoptosis. In the central nervous system activated NF-kappaB plays a neuroprotective role. While in some neurodegenerative disorders the role of NF-kappaB is well characterized, there is poor knowledge on the role of NF-kappaB in prion disease. We found binding but no transcriptional activity of the transcription...    »
 
Journal title abbreviation:
Cell Microbiol 
Year:
2007 
Journal volume:
Journal issue:
Pages contribution:
2202-17 
Language:
eng 
Print-ISSN:
1462-5814 
TUM Institution:
II. Medizinische Klinik und Poliklinik