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Dokumenttyp:
journal article 
Autor(en):
Fritsch, RM; Schneider, G; Saur, D; Scheibel, M; Schmid, RM 
Titel:
Translational repression of MCL-1 couples stress-induced eIF2 alpha phosphorylation to mitochondrial apoptosis initiation. 
Abstract:
The integrated stress response (ISR) integrates a broad range of environmental and endogenous stress signals to the phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 (eIF2 alpha). Although intense or prolonged activation of this pathway is known to induce apoptosis, the molecular mechanisms coupling stress-induced eIF2 alpha phosphorylation to the cell death machinery have remained incompletely understood. In this study, we characterized apoptosis initiation in r...    »
 
Zeitschriftentitel:
J Biol Chem 
Jahr:
2007 
Band / Volume:
282 
Heft / Issue:
31 
Seitenangaben Beitrag:
22551-62 
Sprache:
eng 
Print-ISSN:
0021-9258 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik