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Document type:
journal article 
Author(s):
Fritsch, RM; Schneider, G; Saur, D; Scheibel, M; Schmid, RM 
Title:
Translational repression of MCL-1 couples stress-induced eIF2 alpha phosphorylation to mitochondrial apoptosis initiation. 
Abstract:
The integrated stress response (ISR) integrates a broad range of environmental and endogenous stress signals to the phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 (eIF2 alpha). Although intense or prolonged activation of this pathway is known to induce apoptosis, the molecular mechanisms coupling stress-induced eIF2 alpha phosphorylation to the cell death machinery have remained incompletely understood. In this study, we characterized apoptosis initiation in r...    »
 
Journal title abbreviation:
J Biol Chem 
Year:
2007 
Journal volume:
282 
Journal issue:
31 
Pages contribution:
22551-62 
Language:
eng 
Print-ISSN:
0021-9258 
TUM Institution:
II. Medizinische Klinik und Poliklinik