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Document type:
journal article 
Author(s):
Schmitz, F; Heit, A; Guggemoos, S; Krug, A; Mages, J; Schiemann, M; Adler, H; Drexler, I; Haas, T; Lang, R; Wagner, H 
Title:
Interferon-regulatory-factor 1 controls Toll-like receptor 9-mediated IFN-beta production in myeloid dendritic cells. 
Abstract:
Activation of interferon regulatory factor (IRF)-3 and/or IRF-7 drives the expression of antiviral genes and the production of alpha/beta IFN, a hallmark of antiviral responses triggered by Toll-like receptors (TLR). Here we describe a novel antiviral signaling pathway operating in myeloid (m) dendritic cells (DC) and macrophages that does not require IRF-3 and/or IRF-7 but is driven by IRF-1. IRF-1 together with myeloid differentiation factor 88 (MyD88) or IL-1 receptor-associated kinase (IRAK)...    »
 
Journal title abbreviation:
Eur J Immunol 
Year:
2007 
Journal volume:
37 
Journal issue:
Pages contribution:
315-27 
Language:
eng 
Print-ISSN:
0014-2980 
TUM Institution:
r Medizinische Mikrobiologie, Immunologie und Hygiene; II. Medizinische Klinik und Poliklinik; r Virologie