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Document type:
journal article 
Author(s):
Greten, FR; Arkan, MC; Bollrath, J; Hsu, LC; Goode, J; Miething, C; Göktuna, SI; Neuenhahn, M; Fierer, J; Paxian, S; Van Rooijen, N; Xu, Y; O'Cain, T; Jaffee, BB; Busch, DH; Duyster, J; Schmid, RM; Eckmann, L; Karin, M 
Title:
NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta. 
Abstract:
IKKbeta-dependent NF-kappaB activation plays a key role in innate immunity and inflammation, and inhibition of IKKbeta has been considered as a likely anti-inflammatory therapy. Surprisingly, however, mice with a targeted IKKbeta deletion in myeloid cells are more susceptible to endotoxin-induced shock than control mice. Increased endotoxin susceptibility is associated with elevated plasma IL-1beta as a result of increased pro-IL-1beta processing, which was also seen upon bacterial infection. In...    »
 
Journal title abbreviation:
Cell 
Year:
2007 
Journal volume:
130 
Journal issue:
Pages contribution:
918-31 
Language:
eng 
Print-ISSN:
0092-8674 
TUM Institution:
II. Medizinische Klinik und Poliklinik; III. Medizinische Klinik und Poliklinik; r Medizinische Mikrobiologie, Immunologie und Hygiene