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Document type:
journal article 
Author(s):
von Delius, S; Eckel, F; Wagenpfeil, S; Mayr, M; Stock, K; Kullmann, F; Obermeier, F; Erdmann, J; Schmelz, R; Quasthoff, S; Adelsberger, H; Bredenkamp, R; Schmid, RM; Lersch, C 
Title:
Carbamazepine for prevention of oxaliplatin-related neurotoxicity in patients with advanced colorectal cancer: Final results of a randomised, controlled, multicenter phase II study. 
Abstract:
Background: Oxaliplatin-induced neurotoxicity is a growing, relevant clinical problem. In this study we evaluated the efficacy and safety of carbamazepine for prevention of oxaliplatin-associated neuropathy in patients with advanced colorectal cancer. Methods: Chemotherapeutic treatment consisted of oxaliplatin 85 mg/m(2) given biweekly and weekly folinic acid 500 mg/m(2) followed by a 24-h infusion of 5-FU 2000 mg/m(2) (FUFOX). One cycle consisted of six consecutive weeks of treatment followed...    »
 
Journal title abbreviation:
Invest New Drugs 
Year:
2007 
Journal volume:
25 
Journal issue:
Pages contribution:
173-80 
Language:
eng 
Print-ISSN:
0167-6997 
TUM Institution:
II. Medizinische Klinik und Poliklinik; r Medizinische Statistik und Epidemiologie; r Neurowissenschaften