User: Guest  Login
Document type:
journal article 
Author(s):
Kannemeier, C; Shibamiya, A; Nakazawa, F; Trusheim, H; Ruppert, C; Markart, P; Song, Y; Tzima, E; Kennerknecht, E; Niepmann, M; von Bruehl, ML; Sedding, D; Massberg, S; Günther, A; Engelmann, B; Preissner, KT 
Title:
Extracellular RNA constitutes a natural procoagulant cofactor in blood coagulation. 
Abstract:
Upon vascular injury, locally controlled haemostasis prevents life-threatening blood loss and ensures wound healing. Intracellular material derived from damaged cells at these sites will become exposed to blood components and could contribute to blood coagulation and pathological thrombus formation. So far, the functional and mechanistic consequences of this concept are not understood. Here, we present in vivo and in vitro evidence that different forms of eukaryotic and prokaryotic RNA serve as...    »
 
Journal title abbreviation:
Proc Natl Acad Sci U S A 
Year:
2007 
Journal volume:
104 
Journal issue:
15 
Pages contribution:
6388-93 
Language:
eng 
Print-ISSN:
0027-8424 
TUM Institution:
I. Medizinische Klinik und Poliklinik