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Dokumenttyp:
journal article 
Autor(en):
Merl, S; Wessely, R 
Titel:
Anti-coxsackieviral efficacy of RNA interference is highly dependent on genomic target selection and emergence of escape mutants. 
Abstract:
Enteroviral diseases are widespread and impose significant importance in medicine. Although the outcome of diseases that are associated with enteroviruses such as myocarditis, pancreatitis, hepatitis, or encephalomyelitis might be fatal, no specific antiviral therapy is yet available. We and others have shown that RNA interference (RNAi) effectively limits picornaviral replication and cytopathogenicity and improves survival in susceptible mice. However, little is known about the dependence of sh...    »
 
Zeitschriftentitel:
Oligonucleotides 
Jahr:
2007 
Band / Volume:
17 
Heft / Issue:
Seitenangaben Beitrag:
44-53 
Sprache:
eng 
Print-ISSN:
1545-4576 
TUM Einrichtung:
I. Medizinische Klinik und Poliklinik