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Dokumenttyp:
journal article 
Autor(en):
Wessely, R; Blaich, B; Belaiba, RS; Merl, S; Görlach, A; Kastrati, A; Schömig, A 
Titel:
Comparative characterization of cellular and molecular anti-restenotic profiles of paclitaxel and sirolimus. Implications for local drug delivery. 
Abstract:
Pleiotropic anti-restenotic properties of drugs that are eluted from coated stents are critical for efficacy and safety. Little is known about comparative drug properties in appropriate human coronary target cell lines for the two compounds that are utilized on FDA-approved drug-eluting stent (DES) platforms, paclitaxel (PTX) and sirolimus (SRL). Target cell lines that play a pivotal role for the pathogenesis of restenosis and vascular healing include human coronary artery smooth muscle (CASMC)...    »
 
Zeitschriftentitel:
Thromb Haemost 
Jahr:
2007 
Band / Volume:
97 
Heft / Issue:
Seitenangaben Beitrag:
1003-12 
Sprache:
eng 
Print-ISSN:
0340-6245 
TUM Einrichtung:
r Kinderkardiologie und angeborene Herzfehler; I. Medizinische Klinik und Poliklinik