Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Tiroch, K; Koch, W; von Beckerath, N; Kastrati, A; Schömig, A 
Titel:
Heme oxygenase-1 gene promoter polymorphism and restenosis following coronary stenting. 
Abstract:
AIMS: Gene expression analyses, cell culture experiments, animal models, and association studies suggest a protective role of the heme oxygenase-1 (HO-1) protein against restenosis. The length of a polymorphic (GT)n dinucleotid repeats sequence in the HO-1 gene promoter influences the transcriptional activity. We evaluated, whether an association existed between this polymorphism and the incidence of restenosis after coronary stenting. METHODS AND RESULTS: Of the 1807 consecutive patients included in this study, 1357 (75%) patients had 6 months follow-up angiography. Restenosis, the primary endpoint, was defined as angiographic restenosis, diameter stenosis of> or =50%, and clinical restenosis, target vessel revascularization during the first year. The combined 1 year incidence of death and myocardial infarction (MI) was evaluated as secondary endpoint. We divided the alleles similar to previous studies: class S less repeats (<25), and class L more repeats (> or =25), leading to SS, SL, and LL genotypes. Angiographic restenosis rate showed no significant difference for the studied genotypes-SS 29.2%, SL 29.5%, and LL genotype 29.6% (P = 0.99). There was no significant difference regarding clinical restenosis (P = 0.28) and combined incidence of death or MI (P = 0.98). CONCLUSION: This study does not support a clinically relevant association of the HO-1 promoter polymorphism with restenosis and ischaemic events after coronary stenting. 
Zeitschriftentitel:
Eur Heart J 
Jahr:
2007 
Band / Volume:
28 
Heft / Issue:
Seitenangaben Beitrag:
968-73 
Sprache:
eng 
Print-ISSN:
0195-668X 
TUM Einrichtung:
I. Medizinische Klinik und Poliklinik