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Document type:
journal article 
Author(s):
Steinbach, S; Lutz, J 
Title:
Glutamate induces apoptosis in cultured spiral ganglion explants. 
Abstract:
Traumatic sound exposure, aminoglycoside antibiotics, cochlea ischemia or traumatic stress leads to an excessive release of glutamate from inner hair cells into the synaptic cleft. The high glutamate concentration can cause a swelling and destruction of the dendrites of spiral ganglion neurons of type I as well as a reduction in the number of neurons. This may be a cause of hearing loss. The mechanism causing the reduction of neurons is still not known. Apoptosis, also called programmed cell dea...    »
 
Journal title abbreviation:
Biochem Biophys Res Commun 
Year:
2007 
Journal volume:
357 
Journal issue:
Pages contribution:
14-9 
Language:
eng 
Print-ISSN:
0006-291X 
TUM Institution:
Hals-, Nasen-, Ohrenklinik und Poliklinik; r Nephrologie