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Document type:
journal article 
Author(s):
Penz, SM; Reininger, AJ; Toth, O; Deckmyn, H; Brandl, R; Siess, W 
Title:
Glycoprotein Ibalpha inhibition and ADP receptor antagonists, but not aspirin, reduce platelet thrombus formation in flowing blood exposed to atherosclerotic plaques. 
Abstract:
Anti-platelet drugs are used to prevent intra-arterial thrombus formation after rupture of atherosclerotic plaques. Until now, the inhibitory effect of present and future anti-platelet drugs such as aspirin, ADP receptor P2Y(1)/P2Y(12) antagonists and glycoprotein (GP) Ibalpha inhibitors on the interaction of platelets with human plaques is not known. To study those effects we obtained human atherosclerotic plaques by surgical endarterectomy. Plaques induced maximal platelet aggregation in hirud...    »
 
Journal title abbreviation:
Thromb Haemost 
Year:
2007 
Journal volume:
97 
Journal issue:
Pages contribution:
435-43 
Language:
eng 
Print-ISSN:
0340-6245 
TUM Institution:
chirurgie