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Document type:
journal article 
Author(s):
Tarcha, PJ; Pelisek, J; Merdan, T; Waters, J; Cheung, K; von Gersdorff, K; Culmsee, C; Wagner, E 
Title:
Synthesis and characterization of chemically condensed oligoethylenimine containing beta-aminopropionamide linkages for siRNA delivery. 
Abstract:
Polyethylenimines (PEI) are often inefficient in gene knockdown experiments with small interfering RNA (siRNA), presumably due to the strong complexing properties. A more efficient and potentially degradable oligoethylenimine-based carrier was synthesized by the condensation of 800 molecular weight PEI oligomers with hexanedioldiacrylate. Reaction conditions were chosen such that Michael reaction occurs followed by complete N-acylation of all residual ester bonds resulting in beta-aminopropionam...    »
 
Journal title abbreviation:
Biomaterials 
Year:
2007 
Journal volume:
28 
Journal issue:
25 
Pages contribution:
3731-40 
Language:
eng 
Print-ISSN:
0142-9612 
TUM Institution:
chirurgie