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Document type:
journal article 
Author(s):
Chan, CY; Kiechle, M; Manivasakam, P; Schiestl, RH 
Title:
Ionizing radiation and restriction enzymes induce microhomology-mediated illegitimate recombination in Saccharomyces cerevisiae. 
Abstract:
DNA double-strand breaks can be repaired by illegitimate recombination without extended sequence homology. A distinct mechanism namely microhomology-mediated recombination occurs between a few basepairs of homology that is associated with deletions. Ionizing radiation and restriction enzymes have been shown to increase the frequency of nonhomologous integration in yeast. However, the mechanism of such enhanced recombination events is not known. Here, we report that both ionizing radiation and re...    »
 
Journal title abbreviation:
Nucleic Acids Res 
Year:
2007 
Journal volume:
35 
Journal issue:
15 
Pages contribution:
5051-9 
Language:
eng 
Print-ISSN:
0305-1048 
TUM Institution:
Frauenklinik und Poliklinik