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Dokumenttyp:
journal article 
Autor(en):
Vaclavicek, A; Bermejo, JL; Wappenschmidt, B; Meindl, A; Sutter, C; Schmutzler, RK; Kiechle, M; Bugert, P; Burwinkel, B; Bartram, CR; Hemminki, K; Försti, A 
Titel:
Genetic variation in the major mitotic checkpoint genes does not affect familial breast cancer risk. 
Abstract:
Aneuploidy, an aberrant number of chromosomes, is a very common characteristic of many types of cancers, including tumors of the breast. There is increasing evidence that defects in the spindle assembly checkpoint, which controls correct chromosome segregation between two daughter cells, might contribute to tumorigenesis. In the present study we examined the effect of promoter and coding single nucleotide polymorphisms (SNPs) in six major spindle checkpoint genes (BUB1B, BUB3, CENPE, MAD2L1, MAD...    »
 
Zeitschriftentitel:
Breast Cancer Res Treat 
Jahr:
2007 
Band / Volume:
106 
Heft / Issue:
Seitenangaben Beitrag:
205-13 
Sprache:
eng 
Print-ISSN:
0167-6806 
TUM Einrichtung:
Frauenklinik und Poliklinik