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Document type:
journal article 
Author(s):
Couch, FJ; Sinilnikova, O; Vierkant, RA; Pankratz, VS; Fredericksen, ZS; Stoppa-Lyonnet, D; Coupier, I; Hughes, D; Hardouin, A; Berthet, P; Peock, S; Cook, M; Baynes, C; Hodgson, S; Morrison, PJ; Porteous, ME; Jakubowska, A; Lubinski, J; Gronwald, J; Spurdle, AB; kConFab; Schmutzler, R; Versmold, B; Engel, C; Meindl, A; Sutter, C; Horst, J; Schaefer, D; Offit, K; Kirchhoff, T; Andrulis, IL; Ilyushik, E; Glendon, G; Devilee, P; Vreeswijk, MP; Vasen, HF; Borg, A; Backenhorn, K; Struewing, JP; Gree...    »
 
Title:
AURKA F31I polymorphism and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a consortium of investigators of modifiers of BRCA1/2 study. 
Abstract:
The AURKA oncogene is associated with abnormal chromosome segregation and aneuploidy and predisposition to cancer. Amplification of AURKA has been detected at higher frequency in tumors from BRCA1 and BRCA2 mutation carriers than in sporadic breast tumors, suggesting that overexpression of AURKA and inactivation of BRCA1 and BRCA2 cooperate during tumor development and progression. The F31I polymorphism in AURKA has been associated with breast cancer risk in the homozygous state in prior studies...    »
 
Journal title abbreviation:
Cancer Epidemiol Biomarkers Prev 
Year:
2007 
Journal volume:
16 
Journal issue:
Pages contribution:
1416-21 
Language:
eng 
Print-ISSN:
1055-9965 
TUM Institution:
Frauenklinik und Poliklinik