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Dokumenttyp:
journal article 
Autor(en):
Burges, A; Wimberger, P; Kümper, C; Gorbounova, V; Sommer, H; Schmalfeldt, B; Pfisterer, J; Lichinitser, M; Makhson, A; Moiseyenko, V; Lahr, A; Schulze, E; Jäger, M; Ströhlein, MA; Heiss, MM; Gottwald, T; Lindhofer, H; Kimmig, R 
Titel:
Effective relief of malignant ascites in patients with advanced ovarian cancer by a trifunctional anti-EpCAM x anti-CD3 antibody: a phase I/II study. 
Abstract:
PURPOSE: Malignant ascites in ovarian carcinoma patients is associated with poor prognosis and reduced quality of life. The trifunctional antibody catumaxomab (anti-EpCAM x anti-CD3) enhances the antitumor activity by redirecting T cells and Fcgamma receptor I/III--positive accessory cells to the tumor. This multicenter phase I/II dose-escalating study investigated tolerability and efficacy of i.p. catumaxomab application in ovarian cancer patients with malignant ascites containing epithelial ce...    »
 
Zeitschriftentitel:
Clin Cancer Res 
Jahr:
2007 
Band / Volume:
13 
Heft / Issue:
13 
Seitenangaben Beitrag:
3899-905 
Sprache:
eng 
Print-ISSN:
1078-0432 
TUM Einrichtung:
Frauenklinik und Poliklinik