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Document type:
journal article 
Author(s):
Ben Fredj, R; Gross, E; Chouchen, L; B'Chir, F; Ben Ahmed, S; Neubauer, S; Kiechle, M; Saguem, S 
Title:
Mutational spectrum of dihydropyrimidine dehydrogenase gene (DPYD) in the Tunisian population. 
Abstract:
Dihydropyrimidine dehydrogenase enzyme (DPD) deficiency is a pharmacogenetic syndrome leading to severe side-effects in patients receiving therapies containing the anticancer drug 5-fluorouracil (5-FU). The aim of this population study is to evaluate gene variations in the coding region of the dihydropyrimidine dehydrogenase gene (DPYD) in the Tunisian population. One hundred and six unrelated healthy Tunisian volunteers were genotyped by denaturing HPLC (DHPLC). Twelve variants in the coding re...    »
 
Journal title abbreviation:
C R Biol 
Year:
2007 
Journal volume:
330 
Journal issue:
10 
Pages contribution:
764-9 
Language:
eng 
Print-ISSN:
1631-0691 
TUM Institution:
Frauenklinik und Poliklinik