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Dokumenttyp:
journal article 
Autor(en):
Frank, B; Hemminki, K; Meindl, A; Wappenschmidt, B; Sutter, C; Kiechle, M; Bugert, P; Schmutzler, RK; Bartram, CR; Burwinkel, B 
Titel:
BRIP1 (BACH1) variants and familial breast cancer risk: a case-control study. 
Abstract:
BACKGROUND: Inactivating and truncating mutations of the nuclear BRCA1-interacting protein 1 (BRIP1) have been shown to be the major cause of Fanconi anaemia and, due to subsequent alterations of BRCA1 function, predispose to breast cancer (BC). METHODS: We investigated the effect of BRIP1 -64G>A and Pro919Ser on familial BC risk by means of TaqMan allelic discrimination, analysing BRCA1/BRCA2 mutation-negative index patients of 571 German BC families and 712 control individuals. RESULTS: No sig...    »
 
Zeitschriftentitel:
BMC Cancer 
Jahr:
2007 
Band / Volume:
Seitenangaben Beitrag:
83 
Sprache:
eng 
TUM Einrichtung:
Frauenklinik und Poliklinik