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Dokumenttyp:
journal article 
Autor(en):
Vaclavicek, A; Bermejo, JL; Schmutzler, RK; Sutter, C; Wappenschmidt, B; Meindl, A; Kiechle, M; Arnold, N; Weber, BH; Niederacher, D; Burwinkel, B; Bartram, CR; Hemminki, K; Försti, A 
Titel:
Polymorphisms in the Janus kinase 2 (JAK)/signal transducer and activator of transcription (STAT) genes: putative association of the STAT gene region with familial breast cancer. 
Abstract:
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway mediates the signals of a wide range of cytokines, growth factors and hormones. Thus, aberrant activation of the JAK/STAT pathway may predispose to malignancy due to deregulation of proliferation, differentiation or apoptosis. In this study, we investigated whether genetic variation in the JAK2 gene and the STAT gene region (STAT3, STAT5A and STAT5B) is associated with breast cancer (BC) risk. We carried out a...    »
 
Zeitschriftentitel:
Endocr Relat Cancer 
Jahr:
2007 
Band / Volume:
14 
Heft / Issue:
Seitenangaben Beitrag:
267-77 
Sprache:
eng 
Print-ISSN:
1351-0088 
TUM Einrichtung:
Frauenklinik und Poliklinik