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Document type:
journal article 
Author(s):
Götze, KS; Schiemann, M; Marz, S; Jacobs, VR; Debus, G; Peschel, C; Oostendorp, RA 
Title:
CD133-enriched CD34(-) (CD33/CD38/CD71)(-) cord blood cells acquire CD34 prior to cell division and hematopoietic activity is exclusively associated with CD34 expression. 
Abstract:
We compared the cell division behavior of CD34(-) and CD34(+) (CD33/CD38/CD71)-negative (Lin(-)) CD133(+) cord blood cells stimulated with the cytokines Flt3-ligand, stem cell factor, and thrombopoietin. Within a 4-day time frame, Lin(-)CD34(-) CD133(+) (CD34(-)) cells underwent more cell divisions in serum-free culture than their Lin(-)CD34(+) CD133(+) (CD34(+)) counterparts. The majority of CD34(-) cells acquired expression of CD34 in vitro, including most undivided cells. Moreover, hematopoie...    »
 
Journal title abbreviation:
Exp Hematol 
Year:
2007 
Journal volume:
35 
Journal issue:
Pages contribution:
1408-14 
Language:
eng 
Print-ISSN:
0301-472X 
TUM Institution:
III. Medizinische Klinik und Poliklinik; Frauenklinik und Poliklinik