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Document type:
journal article 
Author(s):
Hüttinger, C; Hirschberger, J; Jahnke, A; Köstlin, R; Brill, T; Plank, C; Küchenhoff, H; Krieger, S; Schillinger, U 
Title:
Neoadjuvant gene delivery of feline granulocyte-macrophage colony-stimulating factor using magnetofection for the treatment of feline fibrosarcomas: a phase I trial. 
Abstract:
Despite aggressive pre- or postoperative treatment, feline fibrosarcomas have high recurrence rates. Immunostimulatory gene therapy is a promising approach in veterinary oncology. This phase I dose-escalation study was performed to determine toxicity and feasibility of gene therapy with feline granulocyte-macrophage colony-stimulating factor (feGM-CSF) in cats with fibrosarcomas. Twenty cats were treated with plasmid coding for feGM-CSF attached to magnetic nanoparticles in doses of 50, 250, 750...    »
 
Journal title abbreviation:
J Gene Med 
Year:
2008 
Journal volume:
10 
Journal issue:
Pages contribution:
655-67 
Language:
eng 
Print-ISSN:
1099-498X 
TUM Institution:
r experimentelle Onkologie und Therapieforschung