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Dokumenttyp:
journal article 
Autor(en):
Hüttinger, C; Hirschberger, J; Jahnke, A; Köstlin, R; Brill, T; Plank, C; Küchenhoff, H; Krieger, S; Schillinger, U 
Titel:
Neoadjuvant gene delivery of feline granulocyte-macrophage colony-stimulating factor using magnetofection for the treatment of feline fibrosarcomas: a phase I trial. 
Abstract:
Despite aggressive pre- or postoperative treatment, feline fibrosarcomas have high recurrence rates. Immunostimulatory gene therapy is a promising approach in veterinary oncology. This phase I dose-escalation study was performed to determine toxicity and feasibility of gene therapy with feline granulocyte-macrophage colony-stimulating factor (feGM-CSF) in cats with fibrosarcomas. Twenty cats were treated with plasmid coding for feGM-CSF attached to magnetic nanoparticles in doses of 50, 250, 750...    »
 
Zeitschriftentitel:
J Gene Med 
Jahr:
2008 
Band / Volume:
10 
Heft / Issue:
Seitenangaben Beitrag:
655-67 
Sprache:
eng 
Print-ISSN:
1099-498X 
TUM Einrichtung:
r experimentelle Onkologie und Therapieforschung