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Document type:
journal article 
Author(s):
DeRouchey, J; Schmidt, C; Walker, GF; Koch, C; Plank, C; Wagner, E; Rädler, JO 
Title:
Monomolecular assembly of siRNA and poly(ethylene glycol)-peptide copolymers. 
Abstract:
In this work, we design and investigate the complex formation of highly uniform monomolecular siRNA complexes utilizing block copolymers consisting of a cationic peptide moiety covalently bound to a poly(ethylene glycol) (PEG) moiety. The aim of the study was to design a shielded siRNA construct containing a single siRNA molecule to achieve a sterically stabilized complex with enhanced diffusive properties in macromolecular networks. Using a 14 lysine-PEG (K14-PEG) linear diblock copolymer, form...    »
 
Journal title abbreviation:
Biomacromolecules 
Year:
2008 
Journal volume:
Journal issue:
Pages contribution:
724-32 
Language:
eng 
Print-ISSN:
1525-7797 
TUM Institution:
r experimentelle Onkologie und Therapieforschung