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Dokumenttyp:
journal article 
Autor(en):
DeRouchey, J; Schmidt, C; Walker, GF; Koch, C; Plank, C; Wagner, E; Rädler, JO 
Titel:
Monomolecular assembly of siRNA and poly(ethylene glycol)-peptide copolymers. 
Abstract:
In this work, we design and investigate the complex formation of highly uniform monomolecular siRNA complexes utilizing block copolymers consisting of a cationic peptide moiety covalently bound to a poly(ethylene glycol) (PEG) moiety. The aim of the study was to design a shielded siRNA construct containing a single siRNA molecule to achieve a sterically stabilized complex with enhanced diffusive properties in macromolecular networks. Using a 14 lysine-PEG (K14-PEG) linear diblock copolymer, form...    »
 
Zeitschriftentitel:
Biomacromolecules 
Jahr:
2008 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
724-32 
Sprache:
eng 
Print-ISSN:
1525-7797 
TUM Einrichtung:
r experimentelle Onkologie und Therapieforschung