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Document type:
journal article 
Author(s):
Bieler, A; Mantwill, K; Holzmüller, R; Jürchott, K; Kaszubiak, A; Stärk, S; Glockzin, G; Lage, H; Grosu, AL; Gansbacher, B; Holm, PS 
Title:
Impact of radiation therapy on the oncolytic adenovirus dl520: Implications on the treatment of glioblastoma. 
Abstract:
BACKGROUND AND PURPOSE: Viral oncolytic therapy is emerging as a new form of anticancer therapy and has shown promising preclinical results, especially in combination with radio- and chemotherapy. We recently reported that nuclear localization of the human transcription factor YB-1 in multidrug-resistant cells facilitates E1-independent adenoviral replication. The aim of this study was to evaluate the combined treatment of the conditionally-replicating adenovirus dl520 and radiotherapy in glioma...    »
 
Journal title abbreviation:
Radiother Oncol 
Year:
2008 
Journal volume:
86 
Journal issue:
Pages contribution:
419-27 
Language:
eng 
Print-ISSN:
0167-8140 
TUM Institution:
Institut für experimentelle Onkologie und Therapieforschung ; Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie