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Document type:
journal article 
Author(s):
Kaszubiak, A; Holm, PS; Lage, H 
Title:
Overcoming the classical multidrug resistance phenotype by adenoviral delivery of anti-MDR1 short hairpin RNAs and ribozymes. 
Abstract:
Simultaneous resistance of cancer cells to multiple cytotoxic drugs, multidrug resistance (MDR), is the major limitation to the successful chemotherapeutic treatment of disseminated neoplasms. The'classical' MDR phenotype is conferred by MDR1/P-glycoprotein (MDR1/P-gp) that is expressed in almost 50% of human cancers. Recent developments in the use of small interfering RNAs for specific inhibition of gene expression have highlighted their potential use as therapeutic agents. DNA cassettes encodi...    »
 
Journal title abbreviation:
Int J Oncol 
Year:
2007 
Journal volume:
31 
Journal issue:
Pages contribution:
419-30 
Language:
eng 
Print-ISSN:
1019-6439 
TUM Institution:
r experimentelle Onkologie und Therapieforschung