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Document type:
journal article 
Author(s):
Kaszubiak, A; Kupstat, A; Müller, U; Hausmann, R; Holm, PS; Lage, H 
Title:
Regulation of MDR1 gene expression in multidrug-resistant cancer cells is independent from YB-1. 
Abstract:
The MDR1 gene encoded transmembrane ABC-transporter MDR1/P-glycoprotein can mediate the phenotype of multidrug resistance (MDR), a major obstacle in the clinical management of cancer patients. It was hypothesized that YB-1 is a fundamental regulatory factor of the MDR1 gene in tumor cells and can therewith enhance drug resistance. To analyze the potential impact of YB-1 in MDR cancer cells, two specific anti-YB-1 small interfering RNAs (siRNAs) were designed for transient triggering the gene-sil...    »
 
Journal title abbreviation:
Biochem Biophys Res Commun 
Year:
2007 
Journal volume:
357 
Journal issue:
Pages contribution:
295-301 
Language:
eng 
Print-ISSN:
0006-291X 
TUM Institution:
r experimentelle Onkologie und Therapieforschung