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Dokumenttyp:
journal article 
Autor(en):
Mykhaylyk, O; Vlaskou, D; Tresilwised, N; Pithayanukul, P; Moller, W; Plank, C 
Titel:
Magnetic nanoparticle formulations for DNA and siRNA delivery 
Abstract:
Newly synthesized magnetic nanomaterials possess high DNA binding capacity either itself or in the presence of a positively charged lipid-based Metafectene (TM) reagent or branched polyethylene imine 25 kDa. Polyethylene imine (PEI)-modified nanomaterials are able to deliver nucleic acids in cell culture in duplexes. Magnetofection with triplexes of nanomaterials results in higher transduction efficiencies compared to optimal PEI or Metafectene formulations. 90% transient down-regulation of the...    »
 
Zeitschriftentitel:
Journal of magnetism and magnetic materials 
Jahr:
2007 
Band / Volume:
311 
Heft / Issue:
Seitenangaben Beitrag:
275-281 
Sprache:
eng 
Print-ISSN:
0304-8853 
TUM Einrichtung:
r experimentelle Onkologie und Therapieforschung