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Document type:
journal article 
Author(s):
Mykhaylyk, O; Vlaskou, D; Tresilwised, N; Pithayanukul, P; Moller, W; Plank, C 
Title:
Magnetic nanoparticle formulations for DNA and siRNA delivery 
Abstract:
Newly synthesized magnetic nanomaterials possess high DNA binding capacity either itself or in the presence of a positively charged lipid-based Metafectene (TM) reagent or branched polyethylene imine 25 kDa. Polyethylene imine (PEI)-modified nanomaterials are able to deliver nucleic acids in cell culture in duplexes. Magnetofection with triplexes of nanomaterials results in higher transduction efficiencies compared to optimal PEI or Metafectene formulations. 90% transient down-regulation of the...    »
 
Journal title abbreviation:
Journal of magnetism and magnetic materials 
Year:
2007 
Journal volume:
311 
Journal issue:
Pages contribution:
275-281 
Language:
eng 
Print-ISSN:
0304-8853 
TUM Institution:
Institut für experimentelle Onkologie und Therapieforschung