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Document type:
journal article 
Author(s):
Brill, TH; Kübler, HR; von Randenborgh, H; Fend, F; Pohla, H; Breul, J; Hartung, R; Paul, R; Schendel, DJ; Gansbacher, B 
Title:
Allogeneic retrovirally transduced, IL-2- and IFN-gamma-secreting cancer cell vaccine in patients with hormone refractory prostate cancer--a phase I clinical trial. 
Abstract:
BACKGROUND: The purpose of this vaccine study was to determine the safety and feasibility of vaccination with an allogeneic prostate carcinoma cell line, LNCaP, expressing recombinant interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) and to evaluate the efficacy of inducing tumor-specific immune responses in HLA-A2-matched patients with hormone refractory prostate cancer (HRPC). METHODS: In a dose-escalating phase I study, HLA-A2-matched HRPC patients received four vaccinations of irradiated...    »
 
Journal title abbreviation:
J Gene Med 
Year:
2007 
Journal volume:
Journal issue:
Pages contribution:
547-60 
Language:
eng 
Print-ISSN:
1099-498X 
TUM Institution:
Institut für experimentelle Onkologie und Therapieforschung ; Institut für Allgemeine Pathologie und pathologische Anatomie