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Document type:
journal article 
Author(s):
Rudolph, C; Sieverling, N; Schillinger, U; Lesina, E; Plank, C; Thünemann, AF; Schönberger, H; Rosenecker, J 
Title:
Thyroid hormone (T3)-modification of polyethyleneglycol (PEG)-polyethyleneimine (PEI) graft copolymers for improved gene delivery to hepatocytes. 
Abstract:
Targeting of gene vectors to liver hepatocytes could offer the opportunity to cure various acquired and inherited diseases. Efficient gene delivery to the liver parenchyma has been obscured from efficient targeting of hepatocytes. Here we show that the thyroid hormone, triiodothyronine (T3), can be used to improve the gene transfer efficiency of nonviral gene vectors to hepatocytes in vitro and to the liver of mice in vivo. T3 conjugated to the distal ends of fluorescent labeled PEG-g-dextran re...    »
 
Journal title abbreviation:
Biomaterials 
Year:
2007 
Journal volume:
28 
Journal issue:
10 
Pages contribution:
1900-11 
Language:
eng 
Print-ISSN:
0142-9612 
TUM Institution:
r experimentelle Onkologie und Therapieforschung