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Dokumenttyp:
journal article 
Autor(en):
Rudolph, C; Sieverling, N; Schillinger, U; Lesina, E; Plank, C; Thünemann, AF; Schönberger, H; Rosenecker, J 
Titel:
Thyroid hormone (T3)-modification of polyethyleneglycol (PEG)-polyethyleneimine (PEI) graft copolymers for improved gene delivery to hepatocytes. 
Abstract:
Targeting of gene vectors to liver hepatocytes could offer the opportunity to cure various acquired and inherited diseases. Efficient gene delivery to the liver parenchyma has been obscured from efficient targeting of hepatocytes. Here we show that the thyroid hormone, triiodothyronine (T3), can be used to improve the gene transfer efficiency of nonviral gene vectors to hepatocytes in vitro and to the liver of mice in vivo. T3 conjugated to the distal ends of fluorescent labeled PEG-g-dextran re...    »
 
Zeitschriftentitel:
Biomaterials 
Jahr:
2007 
Band / Volume:
28 
Heft / Issue:
10 
Seitenangaben Beitrag:
1900-11 
Sprache:
eng 
Print-ISSN:
0142-9612 
TUM Einrichtung:
r experimentelle Onkologie und Therapieforschung