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Document type:
journal article 
Author(s):
El Fitori, J; Su, Y; Büchler, P; Ludwig, R; Giese, NA; Büchler, MW; Quentmeier, H; Hines, OJ; Herr, I; Friess, H 
Title:
PKC 412 small-molecule tyrosine kinase inhibitor: single-compound therapy for pancreatic cancer. 
Abstract:
BACKGROUND: PKC412 is a kinase inhibitor that blocks protein kinase C (PKC), vascular endothelial growth factor receptors, platelet-derived growth factor receptor FLT3, and other class III receptor tyrosine kinases. The enthusiasm for this compound is based on its inhibitory effect even in the case of FLT3 mutations. The aim of this study was to analyze the role of FLT3 in pancreatic cancer and to study the biological activity of combined inhibition of neovascularization and mitogenesis in this...    »
 
Journal title abbreviation:
Cancer 
Year:
2007 
Journal volume:
110 
Journal issue:
Pages contribution:
1457-68 
Language:
eng 
Print-ISSN:
0008-543X 
TUM Institution:
Chirurgiesche Klinik und Poliklinik