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Document type:
journal article 
Author(s):
Harzenetter, MD; Novotny, AR; Gais, P; Molina, CA; Altmayr, F; Holzmann, B 
Title:
Negative regulation of TLR responses by the neuropeptide CGRP is mediated by the transcriptional repressor ICER. 
Abstract:
Communication between the nervous and immune systems involves the release of neuropeptides, such as calcitonin gene-related peptide (CGRP), from sensory nerves during inflammation. CGRP may inhibit the activities of both innate and adaptive immune cells, but the molecular pathways underlying this function are largely unknown. In this study, we identify CGRP as a potent inhibitor of TLR-stimulated production of inflammatory mediators, such as TNF-alpha and CCL4, by murine dendritic cells. Inhibit...    »
 
Journal title abbreviation:
J Immunol 
Year:
2007 
Journal volume:
179 
Journal issue:
Pages contribution:
607-15 
Language:
eng 
Print-ISSN:
0022-1767 
TUM Institution:
Chirurgiesche Klinik und Poliklinik