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Dokumenttyp:
journal article 
Autor(en):
Harzenetter, MD; Novotny, AR; Gais, P; Molina, CA; Altmayr, F; Holzmann, B 
Titel:
Negative regulation of TLR responses by the neuropeptide CGRP is mediated by the transcriptional repressor ICER. 
Abstract:
Communication between the nervous and immune systems involves the release of neuropeptides, such as calcitonin gene-related peptide (CGRP), from sensory nerves during inflammation. CGRP may inhibit the activities of both innate and adaptive immune cells, but the molecular pathways underlying this function are largely unknown. In this study, we identify CGRP as a potent inhibitor of TLR-stimulated production of inflammatory mediators, such as TNF-alpha and CCL4, by murine dendritic cells. Inhibit...    »
 
Zeitschriftentitel:
J Immunol 
Jahr:
2007 
Band / Volume:
179 
Heft / Issue:
Seitenangaben Beitrag:
607-15 
Sprache:
eng 
Print-ISSN:
0022-1767 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik