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Document type:
journal article 
Author(s):
Rohde, F; Rimkus, C; Friederichs, J; Rosenberg, R; Marthen, C; Doll, D; Holzmann, B; Siewert, JR; Janssen, KP 
Title:
Expression of osteopontin, a target gene of de-regulated Wnt signaling, predicts survival in colon cancer. 
Abstract:
Osteopontin (OPN) is a secreted phosphoprotein, which has been reported to be associated with tumor progression in numerous solid tumors. In a previous transcriptome study on colorectal cancer, we identified the gene OPN among the most strongly up-regulated transcripts. OPN has been suggested as a putative target of Wnt signaling, but the molecular mechanism responsible for its aberrant transcription is not fully understood. We analyzed 13 normal colon tissues, 9 adenomas, 120 primary colon tumo...    »
 
Journal title abbreviation:
Int J Cancer 
Year:
2007 
Journal volume:
121 
Journal issue:
Pages contribution:
1717-23 
Language:
eng 
Print-ISSN:
0020-7136 
TUM Institution:
Chirurgiesche Klinik und Poliklinik