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Document type:
journal article 
Author(s):
Rauser, S; Weis, R; Braselmann, H; Feith, M; Stein, HJ; Langer, R; Hutzler, P; Hausmann, M; Lassmann, S; Siewert, JR; Höfler, H; Werner, M; Walch, A 
Title:
Significance of HER2 low-level copy gain in Barrett's cancer: implications for fluorescence in situ hybridization testing in tissues. 
Abstract:
PURPOSE: HER2 may be a relevant biomarker in Barrett's cancer. We compared three HER2 laboratory methods, standard fluorescence in situ hybridization (FISH), image-based three-dimensional FISH in thick (16 microm) sections, and immunohistochemistry, to predict patient outcome. EXPERIMENTAL DESIGN: Tissue microarray sections from 124 Barrett's cancer patients were analyzed by standard FISH on thin (4 microm) sections and by image-based three-dimensional FISH on thick (16 microm) sections for HER2...    »
 
Journal title abbreviation:
Clin Cancer Res 
Year:
2007 
Journal volume:
13 
Journal issue:
17 
Pages contribution:
5115-23 
Language:
eng 
Print-ISSN:
1078-0432 
TUM Institution:
Chirurgiesche Klinik und Poliklinik; r Allgemeine Pathologie und pathologische Anatomie