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Document type:
journal article 
Author(s):
Rimkus, C; Friederichs, J; Rosenberg, R; Holzmann, B; Siewert, JR; Janssen, KP 
Title:
Expression of the mitotic checkpoint gene MAD2L2 has prognostic significance in colon cancer. 
Abstract:
Aneuploidy and genetic instability are a hallmark of colorectal cancer and other solid tumors, and they are thought to enhance tumor progression. The gene MAD2L2 (mitotic arrest deficient 2-like 2) encodes the spindle checkpoint protein MAD2L2 (or MAD2B), a key component of a surveillance system that delays anaphase until all chromosomes are correctly oriented. Defects in this mitotic checkpoint are known to contribute to genetic instability, i.e., numerical and structural aberrations of chromos...    »
 
Journal title abbreviation:
Int J Cancer 
Year:
2007 
Journal volume:
120 
Journal issue:
Pages contribution:
207-11 
Language:
eng 
Print-ISSN:
0020-7136 
TUM Institution:
Chirurgiesche Klinik und Poliklinik