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Document type:
journal article 
Author(s):
Koelwel, C; Rothschenk, S; Fuchs-Koelwel, B; Gabler, B; Lohmann, C; Gopferich, A 
Title:
Alginate inserts loaded with epidermal growth factor for the treatment of keratoconjunctivitis sicca. 
Abstract:
We developed and tested ocular inserts containing epidermal growth factor (EGF) for a causal treatment of keratoconjunctivitis sicca (KCS). The inserts, consisting of different alginates with hydroxyethylcellulose (HEC) as a lubricant and release modifier, released EGF over time periods ranging from a few hours up to several days. The stability of EGF was high, having a protein half-life of approximately 548 days. A clinical pilot study suggests an amelioration of both the main symptoms and the...    »
 
Journal title abbreviation:
Pharm Dev Technol 
Year:
2008 
Journal volume:
13 
Journal issue:
Pages contribution:
221-31 
Language:
eng 
Print-ISSN:
1083-7450 
TUM Institution:
Augenklinik und Poliklinik