Login
Original title:
Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins and structural and biochemical characterization of formins – the actin nucleating factors
Translated title:
Die strukturelle Grundlage für die Inhibition von insulin-like growth factors durch die insulin-like growth factor- binding proteins und die strukturelle und biochemische Eigenschaften von Formin - the actin nucleating factors
Author:
Year:
2007
Document type:
Dissertation
Institution:
Fakultät für Chemie
Advisor:
Huber, Robert (Prof. Dr. Dr. h.c.)
Referee:
Bacher, Adelbert (Prof. Dr. Dr.)
Language:
en
Subject group:
BIO Biowissenschaften
Keywords:
IGF-1, IGFBPs, formins
Translated keywords:
IGF-1, IGFBPs, formin
Abstract:
Insulin-like growth factor binding proteins (IGFBPs) control bioavailability, activity and distribution of IGF-1 and -2 through high-affinity IGFBP-IGF complexes. To analyze the interactions of N- and C-terminal domain of IGFBPs with IGF-1, the several X-ray structures of IGFBP-IGF complexes were determind. These crystal structures provide the molecular basis for the IGFBPs regulation of IGF signaling and support research into the design of IGFBP variants as therapeutic IGF inhibitors for diseas... »
Translated abstract:
Die Insulin-like growth factor binding proteine (IGFBPs) steuern die Bioverfügbarkeit, Aktivität, und Verteilung von IGF-1 und -2 durch die hochaffienen IGFBP-IGF Komplexe. Die beschriebene Kristallstruktur gibt die molekulare Grundlage für die IGFBP Regulation des IGF Signalwegs. Dies unterstützt die Forschung in der Suche/Design nach IGFBP Varianten, die als therapeutische IGF Inhibitoren bei Krankheiten mit einer Disregulation von IGF.
Date of submission:
14.12.2006
Oral examination:
14.06.2007
Pages:
141
Last change:
06.06.2008
BibTeX