User: Guest  Login
Original title:
Functional role of Bcl10 and Malt1 in signal transduction from the FcεRI in mast cells and the LPA receptor in murine embryonic fibroblasts 
Translated title:
Functional role of Bcl10 and Malt1 in signal transduction from the FcεRI in mast cells and the LPA receptor in murine embryonic fibroblasts 
Year:
2008 
Document type:
Dissertation 
Institution:
Fakultät Wissenschaftszentrum Weihenstephan 
Advisor:
Ruland, Jürgen (Priv.-Doz. Dr.) 
Referee:
Ruland, Jürgen (Priv.-Doz. Dr.); Duyster, Justus G. (Prof. Dr.); Wurst, Wolfgang (Prof. Dr.) 
Language:
de 
Subject group:
BIO Biowissenschaften 
Keywords:
Bcl10, Malt1, NF-κB, FcεRI, G-Protein-gekoppelte Rezeptoren 
Translated keywords:
Bcl10, Malt1, NF-κB, FcεRI, G-Protein-gekoppelte Rezeptoren 
Controlled terms:
Mastzelle; Signaltransduktion 
TUM classification:
BIO 220d 
Abstract:
In dieser Arbeit wurden die in Lymphozyten essentiellen Adaptermoleküle B cell lymphoma 10 (Bcl10) und Mucosa-associated lymphoid tissue 1 (Malt1) als neue Schlüsselregulatoren der Signaltransduktion in Mastzellen als exemplarische myeloide Zelllinie identifiziert. Sie regulieren IgE-abhängige, anaphylaktische Langzeitreaktionen in vivo und sind für die FcεRI-induzierte Aktivierung des Transkriptionsfaktors Nuclear Factor κB (NF-κB) und die resultierende Produktion der Zytokine Tumornekrosefakto...    »
 
Translated abstract:
In this work, the essential lymphocyte adaptor molecules B cell lymphoma 10 (Bcl10) and mucosa-associated lymphoid tissue 1 (Malt1) have been identified as novel key regulators in signal transduction in mast cells as exemplary myeloid cell line. They regulate IgE-dependent anaphylactic late phase reactions in vivo and are responsible for the FcεRI-induced activation of the transcription factor nuclear Factor κB (NF-κB) and the resulting production of the cytokines tumor necrosis factor α and int...    »
 
Oral examination:
23.04.2008 
Pages:
118 
Last change:
08.06.2010