User: Guest  Login
Original title:
Molecular cytogenetic analysis of chemically induced aneuploidy in germinal and somatic cells of mice 
Original subtitle:
studies with topoisomerase II inhibitors 
Translated title:
Molekular-zytogenetische Analysen chemisch-induzierter Aneuploidien in Keimzellen und somatischen Zellen der Maus 
Translated subtitle:
Untersuchung zweier Topoisomerase II-Inhibitoren 
Year:
2004 
Document type:
Dissertation 
Institution:
Fakultät Wissenschaftszentrum Weihenstephan 
Advisor:
Kettrup, A. (Univ.-Prof. Dr.) 
Referee:
Adamski, Jerzy (Prof. Dr. Dr. habil.); Parlar, Harun (Prof. Dr. Dr. habil. Dr. h.c.) 
Format:
Text 
Language:
en 
Subject group:
BIO Biowissenschaften; CHE Chemie 
Keywords:
Topoisomerase II (topo II); Etoposide (VP-16); Merbarone (MER); Meiotic delay; Aneuploidy; micronuclei (MN); clastogens; aneugens; Fluorescence in situ hybridisation (FISH); Laser-Scanning Cytometer (LSC) 
Translated keywords:
Topoisomerase II (topo II); Etoposide (VP-16); Merbarone (MER); Aneuploidien; Keimzellen; Knochenmark; Fluoreszenz-in situ-Hybridisierung (FISH); Laser-Scanning Zytometers (LSC); Mikronukleus-Test 
Controlled terms:
Maus; Aneuploidie; Gamet; DNS-Topoisomerasen ; Enzyminhibitor; Etopsid; Barbitursäurederivate; Knochenmarkzelle 
TUM classification:
BIO 770d; BIO 750d; BIO 930d; BIO 220d; CHE 828d 
Abstract:
Aneuploidy is a frequent cause of mental retardation, congenital malformations and pregnancy wastage in human beings. In addition, it is also frequently observed in various stages of carcinogenesis in man. A series of three related but separated studies were conducted to assess the aneugenic effects induced in mouse sperm and bone marrow following etoposide (VP-16) and merbarone (MER) administrations. First, the possibility of a cell cycle delay caused by the test chemicals was assessed using th...    »
 
Translated abstract:
Aneuploidien oder numerische Chromosomenaberrationen sind charakterisiert durch eine Abweichung des normalen diploiden Chromosomensatzes in somatische Zellen oder des haploiden Chromosomensatzes in Keimzellen. Aneuploidien zählen zu den häufigsten chromosomalen Aberrationen in der menschlichen Population; etwa 50 % aller spontanen Aborte sind aneuploid, die Mehrzahl darunter Trisomien. Nur wenige Kinder mit Aneuploidien überleben bis zur Geburt und zeigen meist kongenitale Missbildungen wie kör...    »
 
Publication :
Universitätsbibliothek der TU München 
Oral examination:
10.03.2004 
File size:
1737283 bytes 
Pages:
135 
Last change:
13.04.2007