User: Guest  Login
Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't 
Author(s):
Siegert, S; Huang, HY; Yang, CY; Scarpellino, L; Carrie, L; Essex, S; Nelson, PJ; Heikenwalder, M; Acha-Orbea, H; Buckley, CD; Marsland, BJ; Zehn, D; Luther, SA 
Title:
Fibroblastic reticular cells from lymph nodes attenuate T cell expansion by producing nitric oxide. 
Abstract:
Adaptive immune responses are initiated when T cells encounter antigen on dendritic cells (DC) in T zones of secondary lymphoid organs. T zones contain a 3-dimensional scaffold of fibroblastic reticular cells (FRC) but currently it is unclear how FRC influence T cell activation. Here we report that FRC lines and ex vivo FRC inhibit T cell proliferation but not differentiation. FRC share this feature with fibroblasts from non-lymphoid tissues as well as mesenchymal stromal cells. We identified FR...    »
 
Journal title abbreviation:
PLoS ONE 
Year:
2011 
Journal volume:
Journal issue:
11 
Pages contribution:
e27618 
Language:
eng 
Print-ISSN:
1932-6203 
TUM Institution:
Institut für Virologie