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Dokumenttyp:
journal article 
Autor(en):
Siegert, S; Huang, HY; Yang, CY; Scarpellino, L; Carrie, L; Essex, S; Nelson, PJ; Heikenwalder, M; Acha-Orbea, H; Buckley, CD; Marsland, BJ; Zehn, D; Luther, SA 
Titel:
Fibroblastic reticular cells from lymph nodes attenuate T cell expansion by producing nitric oxide. 
Abstract:
Adaptive immune responses are initiated when T cells encounter antigen on dendritic cells (DC) in T zones of secondary lymphoid organs. T zones contain a 3-dimensional scaffold of fibroblastic reticular cells (FRC) but currently it is unclear how FRC influence T cell activation. Here we report that FRC lines and ex vivo FRC inhibit T cell proliferation but not differentiation. FRC share this feature with fibroblasts from non-lymphoid tissues as well as mesenchymal stromal cells. We identified FR...    »
 
Zeitschriftentitel:
PLoS ONE 
Jahr:
2011 
Band / Volume:
Heft / Issue:
11 
Seitenangaben Beitrag:
e27618 
Sprache:
eng 
TUM Einrichtung:
r Virologie