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Document type:
Journal Article 
Author(s):
Cui, H; Grosso, S; Schelter, F; Mari, B; Kruger, A 
Title:
On the Pro-Metastatic Stress Response to Cancer Therapies: Evidence for a Positive Co-Operation between TIMP-1, HIF-1?, and miR-210. 
Abstract:
In contrast to expectations in the past that tumor starvation or unselective inhibition of proteolytic activity would cure cancer, there is accumulating evidence that microenvironmental stress, such as hypoxia or broad-spectrum inhibition of metalloproteinases can promote metastasis. In fact, malignant tumor cells, due to their genetic and epigenetic instability, are predisposed to react to stress by adaptation and, if the stress persists, by escape and formation of metastasis. Recent recognitio...    »
 
Journal title abbreviation:
Front Pharmacol 
Year:
2012 
Journal volume:
Pages contribution:
134 
Language:
eng 
Fulltext / DOI:
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung