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Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't 
Author(s):
Hartmann, Thomas; Xu, Xinsong; Kronast, Mira; Muehlich, Susanne; Meyer, Kathleen; Zimmermann, Wolfgang; Hurwitz, Jerard; Pan, Zhen-Qiang; Engelhardt, Stefan; Sarikas, Antonio 
Title:
Inhibition of Cullin-RING E3 ubiquitin ligase 7 by simian virus 40 large T antigen. 
Abstract:
Simian virus 40 (SV40) large tumor antigen (LT) triggers oncogenic transformation by inhibition of key tumor suppressor proteins, including p53 and members of the retinoblastoma family. In addition, SV40 transformation requires binding of LT to Cullin 7 (CUL7), a core component of Cullin-RING E3 ubiquitin ligase 7 (CRL7). However, the pathomechanistic effects of LT-CUL7 interaction are mostly unknown. Here we report both in vitro and in vivo experimental evidence that SV40 LT suppresses the ubiq...    »
 
Journal title abbreviation:
Proc Natl Acad Sci U S A 
Year:
2014 
Journal volume:
111 
Journal issue:
Pages contribution:
3371-6 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0027-8424 
TUM Institution:
Institut für Pharmakologie und Toxikologie 
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