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Dokumenttyp:
journal article 
Autor(en):
Hartmann, Thomas; Xu, Xinsong; Kronast, Mira; Muehlich, Susanne; Meyer, Kathleen; Zimmermann, Wolfgang; Hurwitz, Jerard; Pan, Zhen-Qiang; Engelhardt, Stefan; Sarikas, Antonio 
Titel:
Inhibition of Cullin-RING E3 ubiquitin ligase 7 by simian virus 40 large T antigen. 
Abstract:
Simian virus 40 (SV40) large tumor antigen (LT) triggers oncogenic transformation by inhibition of key tumor suppressor proteins, including p53 and members of the retinoblastoma family. In addition, SV40 transformation requires binding of LT to Cullin 7 (CUL7), a core component of Cullin-RING E3 ubiquitin ligase 7 (CRL7). However, the pathomechanistic effects of LT-CUL7 interaction are mostly unknown. Here we report both in vitro and in vivo experimental evidence that SV40 LT suppresses the ubiq...    »
 
Zeitschriftentitel:
Proc Natl Acad Sci U S A 
Jahr:
2014 
Band / Volume:
111 
Heft / Issue:
Seitenangaben Beitrag:
3371-6 
Sprache:
eng 
Print-ISSN:
0027-8424 
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie