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Document type:
Zeitschriftenaufsatz 
Author(s):
Mapesa, Job O.; Waldschmitt, Nadine; Schmoeller, Ingrid; Blume, Carolin; Hofmann, Thomas; Mahungu, Symon; Clavel, Thomas; Haller, Dirk 
Title:
Catechols in caffeic acid phenethyl ester are essential for inhibition of TNF-mediated IP-10 expression through NF-kappaB-dependent but HO-1- and p38-independent mechanisms in mouse intestinal epithelial cells 
Abstract:
SCOPE: Caffeic acid phenethyl ester (CAPE) is an active constituent of honeybee propolis inhibiting nuclear factor (NF)-kappaB. The aims of our study were to provide new data on the functional relevance and mechanisms underlying the role of CAPE in regulating inflammatory processes at the epithelial interface in the gut and to determine the structure/activity relationship of CAPE. METHODS AND RESULTS: CAPE significantly inhibited TNF-induced IP-10 expression in intestinal epithelial cells. Using...    »
 
Journal title:
Molecular nutrition & Food research 
Year:
2011 
Journal volume:
55 
Journal issue:
12 
Pages contribution:
1850--1861 
Fulltext / DOI:
Print-ISSN:
1613-4125