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Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't 
Author(s):
Niki?, Ivana; Merkler, Doron; Sorbara, Catherine; Brinkoetter, Mary; Kreutzfeldt, Mario; Bareyre, Florence M; Brück, Wolfgang; Bishop, Derron; Misgeld, Thomas; Kerschensteiner, Martin 
Title:
A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis. 
Abstract:
In multiple sclerosis, a common inflammatory disease of the central nervous system, immune-mediated axon damage is responsible for permanent neurological deficits. How axon damage is initiated is not known. Here we use in vivo imaging to identify a previously undescribed variant of axon damage in a mouse model of multiple sclerosis. This process, termed 'focal axonal degeneration' (FAD), is characterized by sequential stages, beginning with focal swellings and progressing to axon fragmentation....    »
 
Journal title abbreviation:
Nat Med 
Year:
2011 
Journal volume:
17 
Journal issue:
Pages contribution:
495-9 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
1078-8956 
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)