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Dokumenttyp:
journal article 
Autor(en):
Niki?, Ivana, I; Merkler, Doron, D; Sorbara, Catherine, C; Brinkoetter, Mary, M; Kreutzfeldt, Mario, M; Bareyre, Florence M, FM; Brück, Wolfgang, W; Bishop, Derron, D; Misgeld, Thomas, T; Kerschensteiner, Martin, M 
Titel:
A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis. 
Abstract:
In multiple sclerosis, a common inflammatory disease of the central nervous system, immune-mediated axon damage is responsible for permanent neurological deficits. How axon damage is initiated is not known. Here we use in vivo imaging to identify a previously undescribed variant of axon damage in a mouse model of multiple sclerosis. This process, termed'focal axonal degeneration' (FAD), is characterized by sequential stages, beginning with focal swellings and progressing to axon fragmentation. N...    »
 
Zeitschriftentitel:
Nat Med 
Jahr:
2011 
Band / Volume:
17 
Heft / Issue:
Seitenangaben Beitrag:
495-9 
Sprache:
eng 
Print-ISSN:
1078-8956 
TUM Einrichtung:
r Zellbiologie des Nervensystems