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Document type:
Zeitschriftenaufsatz 
Author(s):
L. Kyselova; D. Kreitmayer; A. Kremling and K. Bettenbrock 
Title:
Type and capacity of glucose transport influences succinate yield in two-stage cultivations 
Abstract:
Background Glucose is the main carbon source of E. coli and a typical substrate in production processes. The main glucose uptake system is the glucose specific phosphotransferase system (Glc-PTS). The PTS couples glucose uptake with its phosphorylation. This is achieved by the concomitant conversion of phosphoenolpyruvate (PEP) to pyruvate. The Glc-PTS is hence unfavorable for the production of succinate as this product is derived from PEP. Results We studied, in a systematic manner, th...    »
 
Keywords:
Succinate production; Two stage cultivations; Glucose transport; Flux balance analysis; APT; Pck 
Journal title:
Open Access Articles and Journals in Engineering 
Year:
2018 
Covered by:
Scopus 
Reviewed:
ja 
Language:
en 
Date of publication:
28.08.2018