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Original title:
Clearance-Mechanismen von Amyloid-β bei der Alzheimer-Krankheit 
Translated title:
Clearance mechanisms of β-amyloid in Alzheimer’s disease 
Year:
2019 
Document type:
Dissertation 
Institution:
Fakultät für Medizin 
Advisor:
Grimmer, Timo (Prof. Dr.) 
Referee:
Grimmer, Timo (Prof. Dr.); Förstl, Johann (Prof. Dr.) 
Language:
de 
Subject group:
MED Medizin; PSY Psychologie 
Keywords:
Amyloid-β, Alzheimer, Neprilysin, Low-Density-Lipoprotein Receptor-related Protein 1, LRP-1, NEP 
Translated keywords:
β-amyloid, Alzheimer, Neprilysin, Low-Density-Lipoprotein Receptor-related Protein 1, LRP-1, NEP 
TUM classification:
MED 600d; PSY 750d 
Abstract:
Eine gestörte Amyloid(Aβ)-Clearance wird als Ursache der sporadischen Alzheimer-Krankheit vermutet. Zwei Clearance-Mechanismen wurden an Patienten untersucht: Das T-Allel des C667T-Polymorphismus des Low-Density-Lipoprotein Receptor-related Protein 1 (LRP-1)-Transportergens korrelierte mit der zerebralen Aβ-Menge. Die anti-amyloiderge Neprilysin-Aktivität im Liquor (NEP) war positiv mit Biomarkern für neuronale Schädigung korreliert und invers mit der Aβ42-Liquorkonzentration. 
Translated abstract:
An impaired amyloid (Aβ) clearance is a suspected cause in sporadic Alzheimer’s disease. Two mechanisms of Aβ clearance have been investigated in patients: The T allele of the C667T polymorphism of the Low-Density-Lipoprotein Receptor-related Protein 1 (LRP-1) transporter gene was positively associated with the cerebral amyloid load. The anti-amyoidogenic NEP activity in the CSF (NEP) was positively associated with biomarkers for neuronal injury and inversely with the CSF-Aβ42 concentration. 
Oral examination:
20.12.2019 
File size:
1142313 bytes 
Pages:
58 
Last change:
24.01.2020