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Document type:
journal article 
Author(s):
Huemer, Florian; Melchardt, Thomas; Jansko, Bettina; Wahida, Adam; Jilg, Stefanie; Jost, Philipp J; Klieser, Eckhard; Steiger, Katja; Magnes, Teresa; Pleyer, Lisa; Greil-Ressler, Sigrun; Rass, Christof; Greil, Richard; Egle, Alexander 
Title:
Durable remissions with venetoclax monotherapy in secondary AML refractory to hypomethylating agents and high expression of BCL-2 and/or BIM. 
Abstract:
Acute myeloid leukemia (AML) is a disease of the elderly population and survival remains poor after failure of hypomethylating agents (HMA). The BCL-2 inhibitor venetoclax demonstrated activity as monotherapy and in combination with chemotherapy or HMA in AML. In this case series, patients with secondary AML (sAML) not eligible for intensive chemotherapy and refractory to HMA were treated with venetoclax within a named patient program at our tertiary cancer center in Salzburg, Austria. Between A...    »
 
Journal title abbreviation:
Eur J Haematol 
Year:
2019 
Journal volume:
102 
Journal issue:
Pages contribution:
437-441 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0902-4441 
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie